Op-brai120166 1..12
نویسندگان
چکیده
Trigeminal autonomic cephalalgias are highly disabling primary headache disorders, characterized by severe unilateral head pain and associated ipsilateral cranial autonomic features. There is limited understanding of their pathophysiology and how and where treatments act to reduce symptoms; this is significantly hindered by a lack of animal models. We have developed the first animal model to explore trigeminal autonomic cephalalgias, using stimulation within the brainstem, at the level of the superior salivatory nucleus, to activate the trigeminal autonomic reflex arc. Using electrophysiological recording of neurons of the trigeminocervical complex and laser Doppler blood flow changes around the ipsilateral lacrimal duct, superior salivatory nucleus stimulation exhibited both neuronal trigeminovascular and cranial autonomic manifestations. These responses were specifically inhibited by the autonomic ganglion blocker hexamethonium bromide. These data demonstrate that brainstem activation may be the driver of both sensory and autonomic symptoms in these disorders, and part of this activation may be via the parasympathetic outflow to the cranial vasculature. Additionally, both sensory and autonomic manifestations were significantly inhibited by highly effective treatments for trigeminal autonomic cephalalgias, such as oxygen, indomethacin and triptans, and some part of their therapeutic action appears to be specifically on the parasympathetic outflow to the cranial vasculature. Treatments more used to migraine, such as naproxen and a calcitonin gene-related peptide receptor inhibitor, olcegepant, were less effective in this model. This is the first model to represent the phenotype of trigeminal autonomic cephalalgias and their response to therapies, and indicates the parasympathetic pathway may be uniquely involved in their pathophysiology and targeted to relieve symptoms.
منابع مشابه
Lab Assignments
Lab Assignments Instrumentation Labs: Name of Lab Assignment: Lab 1 Introductory Experiments and Linear Circuits I [1] Lab 2 Linear Circuits II [2] Lab 3 Semiconductor Diodes [3] Lab 4 JFET Circuits I [4] Lab 5 JFET Circuits II [5] Lab 6 Op Amps I [6] Lab 7 Op Amps II [7] Lab 8 Op Amps III [8] Lab 9 LabVIEW Programming [9] Lab 10 Analog to Digital and Digital to Analog Conversion [10] Lab 11 Si...
متن کاملLab Assignments
Lab Assignments Instrumentation Labs: Name of Lab Assignment: Lab 1 Introductory Experiments and Linear Circuits I [1] Lab 2 Linear Circuits II [2] Lab 3 Semiconductor Diodes [3] Lab 4 JFET Circuits I [4] Lab 5 JFET Circuits II [5] Lab 6 Op Amps I [6] Lab 7 Op Amps II [7] Lab 8 Op Amps III [8] Lab 9 LabVIEW Programming [9] Lab 10 Analog to Digital and Digital to Analog Conversion [10] Lab 11 Si...
متن کاملOsteogenic protein 1 device increases bone formation and bone graft resorption around cementless implants.
In each femoral condyle of 8 Labrador dogs, a non weight-bearing hydroxyapatite-coated implant was inserted surrounded by a 3 mm gap. Each gap was filled with bone allograft or ProOsteon with or without OP-1 delivered in a bovine collagen type I carrier (OP-1 device). 300 microg OP-1 was used in the 0.75 cc gap surrounding the implant. After 3 weeks, the OP-1 device enhanced implant fixation by...
متن کاملHigh doses of vascular endothelial growth factor 165 safely, but transiently, improve myocardial perfusion in no-option ischemic disease.
UNLABELLED Gene therapy can induce angiogenesis in ischemic tissues. The aim of this study was to assess safety, feasibility, and results, both clinical and on myocardial perfusion, of gene therapy in refractory angina. This was a phase I/II, prospective, temporal-controlled series, clinical trial. Thirteen patients were maintained for minimum 6 months under optimized clinical management, and t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012